Abstract Intra-tumoral epigenetic heterogeneity is an indicator of tumor population fitness and is AV linked to the deregulation of transcription.However, there is no published computational tool to automate the measurement of intra-tumoral epigenetic allelic heterogeneity.We developed an R/Bioconductor package, epihet, to calculate the intra-tumor
Abstract Background The Drosophila melanogaster genome contains 29 serpin genes, 12 as single transcripts and 17 within 6 gene clusters.Many of these serpins have a conserved "hinge" motif characteristic of active proteinase inhibitors.However, a substantial proportion (42%) lacks this motif and represents non-inhibitory serpin-fold proteins of unk
Previous studies investigating altruistic punishment have confounded the effects of two independent variables: information transmission (or breach of privacy) and personal identification (or breach of anonymity).Here we PRO-BIOTIK 15B report findings from a brief study in which participants were asked to respond to a social norm violation (i.e., an
Industry needs new materials that present very high structural characteristic, such as high strength, low weight and high damage tolerance.To obtain these characteristics a new class Baby Care of materials has been introduced: Fibre Metal Laminate (FML); they consist in metal sheets alternated to composite material layers: in such manner, the good
Abstract Objective Redox homeostasis maintenance is essential to bring about cellular functions.Particularly, embryonic Cocktail Table with 2 Stools stem cells (ESCs) have high fidelity mechanisms for DNA repair, high activity of different antioxidant enzymes and low levels of oxidative stress.Although the expression and activity of antioxidant enz